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PCP acts as a(n) ________ at ________ receptors.


A) agonist; NMDA
B) antagonist; dopamine
C) agonist; acetylcholine
D) indirect antagonist; NMDA
E) antagonist; GABA

F) A) and D)
G) A) and B)

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The positive symptoms of schizophrenia are reversed by drugs that are


A) agonists at serotonin receptors.
B) dopamine receptor agonists.
C) antagonists at GABA receptors.
D) similar in structure to benzodiazepines.
E) dopamine receptor antagonists.

F) A) and B)
G) A) and C)

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A drug company seeking to develop a new antischizophrenic drug would want to develop a drug that reverses both positive and negative symptoms but that avoids the blockage of ________ receptors within the ________ of the schizophrenic brain.


A) D1; nucleus accumbens
B) D2; medial prefrontal cortex
C) D3; hippocampus
D) D2; striatum
E) D4; amygdala

F) C) and D)
G) B) and C)

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The risk of a child developing schizophrenia is increased by


A) maternal age.
B) his or her sex.
C) paternal age.
D) their ethnic background.
E) educational level.

F) B) and D)
G) D) and E)

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Delusions


A) are beliefs that are contrary to fact.
B) are linked to brain damage.
C) are perceptions that occur without the presence of stimuli.
D) indicate the presence of depression.
E) are common negative symptoms of schizophrenia.

F) All of the above
G) B) and C)

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In MRI studies of brain anatomy in identical twins discordant for schizophrenia, the schizophrenic twin usually


A) had smaller lateral and third ventricles.
B) had larger lateral and third ventricles.
C) had a larger anterior hippocampus.
D) showed a smaller corpus callosum.
E) had a thinner cerebral cortex.

F) A) and B)
G) C) and D)

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A person with severe depression is at greater risk for


A) serious cardiac disease.
B) death by suicide.
C) poor grooming habits.
D) loss of norepinephrine cells within the prefrontal cortex.
E) developing major delusions and unhealthy compulsions.

F) A) and E)
G) B) and E)

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Which class of antidepressant agents have the effect of increasing activity in both serotonin and norepinephrine synapses?


A) cocaine-related stimulants
B) lithium salts
C) SSRIs
D) SNRIs
E) MAOIs

F) B) and D)
G) All of the above

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Administration of high doses of drugs such as ________ would be expected to produce the positive symptoms of schizophrenia.


A) GABA
B) glycine
C) caffeine
D) amphetamine
E) chlorpromazine

F) A) and D)
G) All of the above

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Negative symptoms of schizophrenia


A) represent a lack of normal behaviors.
B) usually require long hospital terms to treat.
C) are associated with low levels of brain dopamine activity.
D) indicate that the patient cannot accurately perceive reality.
E) are specific to schizophrenia.

F) D) and E)
G) None of the above

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The incidence of schizophrenia in the world population is approximately ________ percent.

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The monoamine hypothesis states that depression is caused by


A) loss of cells within the prefrontal cortex.
B) insufficient activity of monoaminergic neurons.
C) excessive activity of dopamine synapses.
D) overactivity of monoaminergic neurons
E) excessive activity of serotonin synapses.

F) A) and C)
G) B) and D)

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A person who believes that he or she is President of the World is most likely suffering from a delusion of ________.

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The phrase "split mind" as it refers to schizophrenia means


A) multiple personalities.
B) delusional thinking.
C) a separation of thoughts and feelings.
D) extreme sadness in the presence of mania.
E) an inability to make important decisions.

F) A) and C)
G) A) and D)

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The ________ symptoms of schizophrenia are the first to appear in the course of the disorder.

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The two major types of symptoms noted in schizophrenia include


A) thought disorder and impaired language ability.
B) hallucinations and social withdrawal.
C) delusions and hallucinations.
D) positive symptoms and negative symptoms.
E) delusions and profound sadness.

F) B) and D)
G) B) and C)

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2-________ of the frontal cortex contributes to the positive symptoms of schizophrenia by increasing the release of dopamine within the nucleus accumbens.

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The majority of schizophrenia cases will develop between the ages of


A) 12-14.
B) 20-24.
C) 30-34.
D) 40-44.
E) 55-59.

F) C) and D)
G) None of the above

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The atypical antipsychotic clozapine produces a(n) ________ activity within the ________.


A) increase in GABA; ventral tegmental area
B) decrease in GABA; ventral tegmental area
C) increase in dopamine; nucleus accumbens
D) decrease in dopamine; hippocampus
E) increase in dopamine; prefrontal cortex

F) A) and E)
G) None of the above

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An example of a positive benefit associated with a manic episode would be


A) intense effort at completing a project.
B) intense euphoria.
C) severe disorganization.
D) increased energy to take on many projects at once.
E) delusions of grandeur.

F) C) and D)
G) B) and E)

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